Data/hora: 03/06/2024 12:17:28

Provedor de dados: | Nature Precedings
País: | United Kingdom
Título: | 3D model of amphioxus steroid receptor complexed with estradiol
Autores: | Michael E. Baker; David J. Chang.
Data: | 2009-06-03
Ano: | 2009
Palavras-chave: | Cancer; Developmental Biology; Bioinformatics; Evolutionary Biology.
Resumo: | The origins of signaling by vertebrate steroids are not fully understood.  An important advance was the report that an estrogen-binding steroid receptor [SR] is present in amphioxus, a basal chordate with a similar body plan as vertebrates.  To investigate the evolution of estrogen binding to steroid receptors, we constructed a 3D model of amphioxus SR complexed with estradiol.  This 3D model indicates that although the SR is activated by estradiol, some interactions between estradiol and human ER[alpha] are not conserved in the SR, which can explain the low affinity of estradiol for the SR.  These differences between the SR and ER[alpha] in the steroid-binding domain are sufficient to suggest that another steroid is the physiological regulator of the SR.  The 3D model predicts that mutation of Glu-346 to Gln will increase the affinity of testosterone for amphioxus SR and elucidate the evolution of steroid binding to nuclear receptors.
Tipo: | Manuscript

Identificador:

http://precedings.nature.com/documents/3316/version/1

oai:nature.com:10101/npre.2009.3316.1

http://hdl.handle.net/10101/npre.2009.3316.1

Fonte: | Nature Precedings
Fonte: | Creative Commons Attribution 3.0 License